Elizabeth Lawlor, M.D., Ph.D., is making progress in the fight against sarcomas — rare, aggressive cancers of the bone and soft tissues that primarily affect children, adolescents and young adults. For years, research advances have lagged behind other tumors, and existing treatments are highly toxic, so the urgency for answers and advanced treatments is great. But recently, Dr. Lawlor’s research team has uncovered fundamental mechanisms that give rise to Ewing sarcoma and other aggressive cancers. This discovery is leading toward new therapies that target cancer cells, stop their spread and prevent relapse. This discovery may profoundly improve treatment options for aggressive cancers, offering hope for thousands of patients like high school student Katelyn Shaver, pictured here, who face this daunting challenge.